REFERENCES:

1. a. Chandley A/C. , and Hargreve,T.B. (1996) Genetic anomaly and ICSI.Human Reprod. 11.,930-932

2. a. Van Opastal et al ( 1997)Determination of the parent of origin in nine cases of prenatally detected chromosome aberrations found after ICSI ,Hum reprod.,12,682-686

3. a. In’t Veld et al (1995)sex chromosomal abnormalities and ICSI .Lancet 346,773

b. Liebaers,I.et al (1997)sex chromosomal abnormalities and after ICSI (letter) Lancet,346, 1095

c. Bonduelle ,M. et al (1998) Incidence of chromosomal aberrations in children born after assisted reproduction through ICSI (editorial ) .Human Reprod. 13.781-782

4. a. Moosani et al (19950Chromosomal analysis of sperm from men with idiopathic infertility using sperm karyotyping and fluorescence in situ hybridization , Feril,Steril. 64, 811-817

b. Bernardini ,L. et al (1997) comparisons of gonosomal anerploidy in spermatozoa if normal fertile men and those with severe male factor detected by in situ hybridization . Mol. Hum. Reprod. 3. 431-438

c. Lahedetie,J. et al (1997) Incidence of anerpolid spermatozoa among infertile men studied by multicolor fluorescence in situ hybridization Am. J. Med. Genet. 71.,115-121

d. McInnes et al (1998) abnormalities for chromosomes 13 and 21 detected in spermatozoa from infertile men . Hum repod. 13, 2787-2790

e. Storeng et al (1998) Incidence of sex chromosome abnormalities in spermatozoa from patients entering and IVF or ICSI protocol . Acta Obstet .Gynecol.Scand. 77,191-197.

f. Pang et al ( 1999) detection of aneuploidy for chromosomes 4,6,7,8,9,10,11,12,13,17,18,21,X and Y by fluorescents in situ hybridization in spermatozoa from nine patients with oligoasthenoteratozoospermia undergoing ICSI Hum Repod. 14, 1266-1273.

g. Ushijima et al (2000) analysis of chromosomal abnormalities in spermatozoa form patients entering an IVF ofr ICSI protocol; Acta Obster.Gynecol Scandin.77,.191-197

h. Vegeti et al (2000) Correlation between semen parameters and sperm aneuploidy rates investigated by fluorescence in situ hybridization in infertile men. Hum Reprod. 15, 351-365

i Calogero A.E. et al (2000) Aneuploidy rate in spermatozoa of selected men with abnormal semen parameters . Hum Reprod. 16., 1172-1179

5. a. Palermo et al ( 1993 ) Sperm characteristic and outcome of human assisted fertilization by subzonal insemination and ICSI Fertl. Steril ,.59, 826-835

6. a. Evenson et al (1980) Relation of mammalian sperm chromatin heterogeneity to fertility . Science , 240, 1131-1133

b. Foresta C. et al (1992) sperm nuclear instability and staining with aniline blue ; abnormal persistence of histones in spermatozoa in infertile men . Int. J. androl,15.,330-337

c. Sailer ,B.L. et al ( 1995) Mammalian sperm DNA susceptibility to in situ denaturation associated with the presence of DNA strand breaks as measured by the terminal deoxynucleotidyl transferase assay. J. Androl., 16.,80-87

7. a. Sakkas Et al(1998) sperm Nuclear DNA damage and altered chromatin structure: effect on fertilization and embryo development . hum Reprod. 13.,(suppl. 4),11-19

b. AhmadiA. Et al (1999) Fertilizing ability of DNA – damaged spermatozoa J. exp.zool, 284 ,696-704

8. a. Lopes,S. et al (1998 b)Sperm deoxuribonucleic acid fragnnebttion is increased in poor quality semen samples and correlates with failed fertilization in ICSI .Fert.Ster 69 , 528 – 532

b. Twig ,J P et al (1998) Oxidatine damage to DNA in human spermatozoa does not preclude proncleus formation at ICSI.Hum.Perod. 13, 1864 – 1871.

c. Ahmadi,A and Ng,S.C. (1999 a) Developmental capacity of damaged spermatozoa .Hum.Reprod. 14,2279-2285

d. .Irvine et al (2000) DNA integrity in human spermatozoa :relationship with semen quality. J.andrology,21, 33-44

9. a . Lee et al (1997) The FAS system is a key regulator of germ cell apoptosis in testis. Endocrinology ,138,2081-1088

b. Tesaril et al (1998) Germ cell apoptosis in men with complete and incomplete spermiogenesis failure . Mol Hum. Reprod. , 4 757-762.

c. Yin et al (1998 ) Heat indused testicular apoptosis occurs independently of hormonal depletion Apoptosis , 3, 281-287.

d.Host et al 91999) DNA strand breaks in human sperm cells : a comparison between men with normal and oligozoospermic sperm samples .acta Obstet. Gynecol. Scand. 78, 336-339

e. Pentikinen et al (1999) Fas regulates germ cells apoptosis in the human testis in vitro. Endocrinol.Metab. 39,E 310-E 316

f. Sakkas et al (1999) Abnormal sperm parameters in humans are indicative of an abortive apoptotic mechanism linked to the Fas- mediated pathway.Exp.cell. Res..,251 , 350-355

g.. Print and Loeland (2000) Germ cell suicide : new insights unto apoptosis during spermatogenesis . BioEssay,22, 423- 430

10. a. Hughes et al (1996) A comparison of baseline and induced DNA damage in human spermatozoa from fertile and infertile men, using a modified Comet assay .MolHum Reprod. 2. 613-619

b. Sun et al ( 1997) detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro. Biol. Reproduc, 56,602-607

11. a. GAndini ,L. et al (2000) Study of apoptotic DNA fragmentation in human spermatozoa . Hum Reprod., 15, 830-839

12. a. Lopes et al (1998 b) refer 8/a.

13. a. Aldo E. C. et al (2001) Aneuploidy rate in spermatozoa of selected men with abnormal semen parameters Hum. Reprod. 16,.1172-1179

14. a. Miller J.E.et al (2001) the effect of ICSI and semen parameters of blastocyst development in vitro Hum Reprod. ,16.,918-924

15. a. Griffiths,T.A. et al (20000 Embryonic development in vitro is compromised by the ICSI procedure .Hum Reprod., 15. 1592-1596

16. a. Fishel ,S. et al (1992) evaluation of 225 patients undergoing subzonal insemination for the procurement of fertilization in vitro .Fertl.Steril. 57,. 840-849

b. Palermo et al ….5/a

c. Van de velde,H. et al ( 1997) Effects of different hyaluronidase concentration and mechanical procedures for cumulus cell removal on the outcome of ICSI Hum. Reprod. 12, 2246-2250

17. a. Sutovsky ,P. et al (1996) ICSI for Rhesus monley fertilization results in unusual chromatin ,cytoskeletal , and membrane events , but eventually leads to promuclear development and sperm aster formation Hum.Reprod. 11.1703-1712

18. a. Calegero A.E. et al (2001) High sperm aneuploidy rate in unselected infertile patients and its relationship with ICSI outcome Hum Reprod. 16.,1433-1439

From: "Alfonso Gutiérrez Adán" <agutierr@inia.es>

To: <ishani6@sancharnet.in>

Subject: reference request

Date: Saturday, October 06, 2001 6:00 AM

Dear Pankar, thanks for your very interesting paper about ICSI (in Embryo Discussion list).

Could you send me the references of the letter, and any paper that you can have about the subject.

Sincerely,

Alfonso Gutiérrez-Adán

INIA SGIT

Dpto Reproduccion Animal

Carretera de la Coruña km 5,9

28040 Madrid

Pho (91) 347 3768

Fax (91) 347 4014

From: "Elena Kontogianni" <elkont@hol.gr>

To: <ishani6@sancharnet.in>

Subject: very interesting article on embryomail

Date: Saturday, October 06, 2001 6:10 AM

Dear Dr Banerji

Please send me the references for your very interesting article on

embryomail.

Thank you

Dr Elena Kontogianni

IVF & GENETICS

Kifisias 296 and Navarinou 40

Halandri 15232

Athens, Greece

tel (30)-1-6859000

fax(30)-1-6859969

www.ivf.gr

elkont@hol.gr

From: "Jun Liu" <jun.liu@rug.ac.be>

To: <ishani6@sancharnet.in>

Subject: references

Date: Saturday, October 06, 2001 7:56 AM

Dear Dr. Banerji,

I appreciate to receive the references to the comment you published in Embryo Mail News - 1439.

Regards,

Jun Liu

******************************

Jun Liu

Infertility Centre,

Gent University Hospital,

De Pintelaan 185,

9000 Gent, Belgium

Tel: +32-(0)9-240-3762

Fax: +32-(0)9-240-4972

From: "Mohamed bedaiwy" <bedaiwymmm@yahoo.com>

To: <ishani6@sancharnet.in>

Date: Saturday, October 06, 2001 8:41 AM

Dear Sir,

I read with great interest your message to the embryo

mail about ICSI. I agree with your alarming signal

and I hope that It will gain much attention from

cliniceans/scientists who are fans of ICSI with and

without indication. Could you please send me the

references you have mentioned in your interesting

message.

Thanks

M. Bedaiwy

Cleveland Clinic

__________________________________________________

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From: "Neal Michael" <nealm@HHSC.CA>

To: <ishani6@sancharnet.in>

Subject: references

Date: Saturday, October 06, 2001 9:00 AM

I read with interest your posting in embryo mail news # 1439. I would be

interested in a copy of the references, and would greatly appreciate if you

would forward them to me.

Regards,

Michael S. Neal

email: nealm@hhsc.ca

This information is directed in confidence solely to the person named above

and may not otherwise be distributed, copied or disclosed. Therefore, this

information should be considered strictly confidential. If you have

received this email in error, please notify the sender immediately via a

return email for further direction. Thank you for your assistance.

From: "Lynda McGinnis" <lmcginnis@hms.harvard.edu>

To: <ishani6@sancharnet.in>

Subject: ICSI REferences

Date: Saturday, October 06, 2001 12:04 PM

Dear Dr Banerji,

We read your interesting presentation on the embryo email list regarding

hazards and detrimental effects of ICSI. Could you please send us a copy

of your reference list?

Thank you,

Lynda K. McGinnis

=======================================

Lynda K McGinnis

Research Associate

Dept of Cell Biology

Harvard Medical School

240 Longwood Ave

Boston, MA 02115

lynda_mcginnis@hms.harvard.edu

From: <n.richings@pgrad.unimelb.edu.au>

To: <ishani6@sancharnet.in>

Subject: ICSI References

Date: Saturday, October 06, 2001 5:25 PM

Dr.D'Pankar Banerji,

could you please send the list of references that you cited in your posting in embryo mail,

thank-you

Nadine Richings

n.richings@pgrad.unimelb.edu.au

From: "mlpapale" <mlpapale@citiesonline.it>

To: <ishani6@sancharnet.in>

Subject: ICSI-References

Date: Saturday, October 06, 2001 11:34 PM

Dear Sir,

was very interesting to read your letter to embyo mail.

I would like to have all references you quoted in your article if possible.

Thanks in advance

My best regards

ML Papale

Dir.of embryo lab

CRA Center of Assisted Reproduction

V.le Odorico da Pordenone,5

95128 Catania, Italy

www.cragroup.it

Tel.+39-095-436595/436628

Fax.+39-095-430779

From: "Perry" <perry@post.tau.ac.il>

To: "Dr D'Pankar Banerjee" <ishani6@sancharnet.in>

Subject: Should we do ICSI at all ?

Date: Sunday, October 07, 2001 2:36 AM

Let me express my deep gratitude for your letter to Embryo Mail News -1439,

which I just received this morning. It provided and excellent critical

review plus evaluation of ICSI and not merely an indexing of the available

publications!

I am a teacher of Mammalian Reproduction at the Tel Aviv University Faculty

of Life Sciences. In my course, I often find it necessary to inject a

cautionary note regarding the use of the newer reproductive technologies,

especially in the human. Your excellent review has confirmed my point of

view in a succinct and clearly stated style. I would like to distribute

copies of your letter to my students for their notes, guaranteeing of course

full acknowledgment of your authorship. Do I have your permission to do so?

From: "Wells, Martha" <wells@cber.fda.gov>

To: <ishani6@sancharnet.in>

Subject: ICSI concern

Date: Sunday, October 07, 2001 6:31 AM

Greetings Dr.D'Pankar Banerji,

I would appreciate it if you would email me the ICSI references you referred

to in your embryo mail. The US Food and Drug Administration is beginning to

implement regulations in this field and we have been exploring safety issues

concerning some of the newer IVF manipulations of reproductive

tissues/cells including ICSI

Thank you

Marty Wells

Human Tissue Staff, CBER, FDA

301-827-6106/ Fax 301-827-2844

From: "michael reed" <mleroyreed@yahoo.com>

To: <ishani6@sancharnet.in>

Subject: request for your references re: embryo mail

Date: Sunday, October 07, 2001 7:17 AM

I appreciate your comments on ICSI. At present, our

clinic has moved reluctantly (on my part) from about

35% of patients for ICSI to about 70% of patients for

ICSI, due primarily to sever morphological problems.

Just this week, the medical director suggested that we

move to 100% ICSI, like some centers. I have been

very reluctant for many reasons, some of which you

have stated. I would appreciate your reference list,

and I'm going to file your comments with my ICSI

information, if you don't mind.

Thank you!

Mike Reed, Ph.D.

Center for Reproductive Medicine of New Mexico

mleroyreed@yahoo.com

__________________________________________________

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From: "Harold Bourne" <bourneh@cryptic.rch.unimelb.edu.au>

To: "Dr.D'Pankar Banerji" <ishani6@sancharnet.in>

Subject: Should we do ICSI at all ?

Date: Sunday, October 07, 2001 4:54 PM

Dear Dr Banerji,

I have just read your comments to embryo-mail regarding the increasing

frequency and consequences of the use of ICSI. It is a difficult question

and I expect there is no correct answer. Any medical treatment carries risk

and it is the responsibilty of the medical community to minimise those

risks, monitor outcomes and advise patients appropriately so that informed

decisions can be made. It would not be right to withhold treatment simply

because of increased risk when the outcome in the vast majority of case

appears normal. Nevertheless, I would agree that the issue of an informed

decision is muddied when a third party (ie the offspring) have not been

born yet.

Could you please forward the list of references qouted in your article?

Thank you for raising this issue. We shall wait and see what responses

there are.

Regards,

Harold Bourne

Scientist in Charge, IVF laboratory

Reproductive Services, Royal Women's Hospital

132 Grattan St., Carlton, Vic, 3053 Australia

Tel: (+ 61 3) 9344 2046

Fax: (+ 61 3) 9349 1387

email: bourneh@cryptic.rch.unimelb.edu.au

From: "Miss R .Singh" <singhr@medic.up.ac.za>

To: <ishani6@sancharnet.in>

Subject: ICSI-References

Date: Sunday, October 07, 2001 11:45 PM

Dear Dr. D' Pankar Banerji,

I read your interesting comments on the embryo mail.

I am actually in the process of writing an assignment on the advantages

and disadvantages of ICSI.

I would really like a copy of the references that you have used if it is

at all possible (email copy is fine).

Thank you in advance.

Raksha Singh

South Africa

IVF Laboratory – Pretoria

From: "Tom McEvoy" <t.mcevoy@ab.sac.ac.uk>

To: <ishani6@sancharnet.in>

Subject: Re: Should we do ICSI at all?

Date: Monday, October 08, 2001 12:23 AM

Dear Dr D'Pankar Banerji

Thank you for your thought-provoking comments in the most recent

'Embryo Mail' bulletin. They were eloquently stated and reflect

some of my own concerns about use of manipulative procedures to

overcome infertility.

I would be most grateful if you could please provide me with a list of

the references to which you referred in your Embryo Mail message.

Many thanks

With kindest regards

Dr Tom McEvoy

Animal Biology Division

SAC, Craibstone Estate,

Bucksburn, Aberdeen AB21 9YA

United Kingdom

tel. 01224 711061

fax. 01224 711292

The information in this email is confidential and may be legally privileged. It is intended solely for the addressee. Access

to this email by anyone else is unauthorised.

If you are not the intended recipient, any disclosure, copying, distribution or any action taken or omitted to be taken in

reliance on it, is prohibited and may be unlawful. When addressed to our clients any opinions or advice contained in this

email are subject to the terms and conditions expressed in the governing client engagement letter.

From: "Gilbert R Holyoak/vms/Cvm" <holyoak@cvm.okstate.edu>

To: "Dr.D'Pankar Banerji" <ishani6@sancharnet.in>

Subject: ICSI references

Date: Monday, October 08, 2001 4:08 AM

Dear Dr. Banerji,

I would appreciate a copy of the references for your embryomail document

entitled "Should we do ICSI at all?"

Thank you,

Reed

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

G. Reed Holyoak, DVM, PhD, Dipl. ACT

Associate Professor, Clinical Theriogenology

Oklahoma State University

Stillwater, OK 74078

405-744-6656

405-744-6265 (fax)

holyoak@okstate.edu

From: "Dean Morbeck" <Dean.Morbeck@NorthMemorial.com>

To: <ishani6@sancharnet.in>

Subject: ICSI

Date: Monday, October 08, 2001 5:25 AM

Dr. Banerji-

I am interested in obtaining the list of references from you review posted on Embryomail. I am not aware of many of these papers and thus would like more information.

There are undoubtedly risks involved with ICSI and thus the procedure should be continuously monitored. The question one needs to ask regards relative risk. It is now apparent that there is an increased risk for some form of genetic effect, but how does this risk compare to the risk already present when doing IVF with eggs from a 40 year-old?

You did an excellent job of presenting your opinion and hopefully stimulating some debate on this topic that we tend to ignore.

Dean E. Morbeck, Ph.D.

dean.morbeck@northmemorial.com

From: "nwora melie" <nworamelie@hotmail.com>

To: <ishani6@sancharnet.in>

Subject: ICSI, How Safe?

Date: Monday, October 08, 2001 6:04 AM

Dear Sir,

Due to the fact that our patients are probably self selecting, we are doing

100% ICSI at our centre.

I've read quite a few papers on the pros and cons of ICSI. However I don't

think I have as many refernces as you'ver qouted. Could you kindly send me

your list.

Kindest regards,

Nwora.

_________________________________________________________________

Get your FREE download of MSN Explorer at http://explorer.msn.com/intl.asp

From: "melanie freeman" <mfreeman@nashvillefertility.com>

To: <ishani6@sancharnet.in>

Subject: ICSI

Date: Monday, October 08, 2001 6:56 AM

Dear Dr. Banerji,

Your comments about ICSI are very interesting. At your convenience, could

you please email me the references that you mentioned in Embryo Mail News

1439.

Thank you,

Melanie R. Freeman, Ph.D.

From: "michael reed" <mleroyreed@yahoo.com>

To: "Dr.D'Pankar Banerji" <ishani6@sancharnet.in>

Subject: Re: request for your references re: embryo mail

Date: Monday, October 08, 2001 8:04 AM

Dr. Banerji:

I would like to thank you for sharing your references,

and for sharing your experiences. I have had this

same discussion with the individual that helps me in

my lab, and her concerns also mirror those presented

in your discussion.

The internet has become a fascinating tool, and it has

also given our patients a tool for managing their own

care. I have had several husbands decline the use of

ICSI, based on readings in popular press and journals,

and so it is not just ourselves that ask these

questions.

I await further discussions on EmbryoMail.

Thank you, and best of wishes to you!

Mike Reed, Ph.D.

Center for Reproductive Medicine of New Mexico

mleroyreed@yahoo.com

--- "Dr.D'Pankar Banerji" <ishani6@sancharnet.in>

wrote:

> My dear Michael

> Exactly same is happening here too.But as an

> independent infertility

> specialist I am runninig an IVF center with My wife

> Dr.Rinku as my

> embryologist.We re here only center opposing this

> technique,literally going

> against the flow of business

> By the way from where you are.I really appreciate

> your feelings.I am getting

> number of letters regarding the same concern,one

> from FDA regaring banning

> the procedure

> Best wishes

> Dr.D'Pankar Banerji

> 1605,South Civil lines,Jabalpur,MP India

> 482001

> PS : references are in attachment

> ----- Original Message -----

> From: "michael reed" <mleroyreed@yahoo.com>

> To: <ishani6@sancharnet.in>

> Sent: Sunday, October 07, 2001 8:16 AM

> Subject: request for your references re: embryo mail

> > I appreciate your comments on ICSI. At present,

> our

> > clinic has moved reluctantly (on my part) from

> about

> > 35% of patients for ICSI to about 70% of patients

> for

> > ICSI, due primarily to sever morphological

> problems.

> > Just this week, the medical director suggested

> that we

> > move to 100% ICSI, like some centers. I have been

> > very reluctant for many reasons, some of which you

> > have stated. I would appreciate your reference

> list,

> > and I'm going to file your comments with my ICSI

> > information, if you don't mind.

> >

> > Thank you!

> >

> > Mike Reed, Ph.D.

> > Center for Reproductive Medicine of New Mexico

> > mleroyreed@yahoo.com

> >

> > __________________________________________________

> > Do You Yahoo!?

> > NEW from Yahoo! GeoCities - quick and easy web

> site hosting, just

> $8.95/month.

> > http://geocities.yahoo.com/ps/info1

> ATTACHMENT part 2 application/msword

name=icsireferences.doc

__________________________________________________

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From: "Peter Ahlering" <pahlering@sherinstitute.com>

To: <ishani6@sancharnet.in>

Subject: icsi

Date: Monday, October 08, 2001 8:52 AM

So very interesting article, I would love the

references. Please let me know the below,

1) should we be recommending sperm donor to all

oligoasthenoteratospermias?

2) Has it been shown that the offspring of these cases have higher

aneuploidy-sex chromosome or otherwise?

3) Do these patients have hgiher miscarriage rate and , if so, has

it been shown that these miscarriages are aneuploidic??

PMAhlering MD

From: "Janine Larson" <larsojan@ohsu.edu>

To: <ishani6@sancharnet.in>

Subject: request for reference list

Date: Monday, October 08, 2001 8:54 AM

Hello Dr. Banerji. Could I please get the reference list referred to in you recent embryomail communication "should we do ICSI?" Thank you, Janine Larson, Oregon Health Sciences University, Portland, Oregon. USA (larsojan@ohsu.edu)

From: "Marina Sansinena" <msansinena@agctr.lsu.edu>

To: <ishani6@sancharnet.in>

Subject: references

Date: Monday, October 08, 2001 7:24 PM

Dr.Banerji,

I appreciate your taking the time for such detailed review of the

implications of ICSI procedures in the human field. I am a Ph.D. student

doing research mostly in nuclear transfer techniques in several domestic

species, and many of the concerns you described are also applicable to NT

micromanipulation. I am interested in a copy of the references you cited in

your message. Thanks again for a good review. Sincerely,

Marina Sansinena

Department of Animal Science

Embryo Biotechnology Laboratory

Louisiana State University

Baton Rouge, LA 70803

225-642-5474 Phone

225-642-0048 FAX

msansinena@agctr.lsu.edu

From: "Gearon, Ceinwen Dr." <CeinwenG@Lister.HCAHealthcare.co.uk>

To: <ishani6@sancharnet.in>

Subject: ref request

Date: Tuesday, October 09, 2001 2:09 AM

Dear Dr Banerji

I would greatly appreciate seeing the references you cited in embryomail.

Although we have a large ICSI programme in our centre we do try and use it

only when absolutely required.

Your posting was very interesting!!

Yours sincerely

Ceinwen Gearon Ph.D.

IVF Laboratory Director

From: "Borut KOVAČIČ" <borut.kov@sb-mb.si>

To: <ishani6@sancharnet.in>

Subject: Reference request

Date: Tuesday, October 09, 2001 5:00 AM

Dear dr. Pankar Banerji,

I am interesting about mentioned references from Embryo mail, which describe ICSI caused cell damages. In our lab we have also studied the causes for fertilization arrest after ICSI. Read: Kovacic and Vlaisavljevic; Mol Reprod Dev, 55,1:197-204, 2000.

Sincerely yours

Borut Kovacic

From: "Ian Lyons" <l7onnais@yahoo.com>

To: <ishani6@sancharnet.in>

Subject: ICSI review

Date: Tuesday, October 09, 2001 5:04 AM

Dear Dr Banerji

I read with interest your review of ICSI, and would appreciate your

sending me the references.

Sincerely

Ian Lyons

BresaGen, Inc

Athens Georgia

USA

--------------------

Subj: Should we do ICSI at all ?

From: Dr.D'Pankar Banerji (ishani6@sancharnet.in)

)(references can be provided on request)

From: "Annick Lefevre" <lefevre@lyon151.inserm.fr>

To: <ishani6@sancharnet.in>

Date: Tuesday, October 09, 2001 6:12 AM

thanks for your nice review on the risks of performing ICSI. I would

greatly appreciate if you could send me the references.

Sincerely yours

Anncik Lefèvre

Dr Annick Elisabeth Lefèvre

INSERM U418

Hopital Debrousse

29 rue Soeur Bouvier

69322, Lyon cedex 05, France

e-mail: lefevre@lyon151.inserm.fr

tel.: 04 78 25 31 13

From: "Aidita James" <aidita@aggienetwork.com>

To: <ishani6@sancharnet.in>

Subject: Reference list

Date: Wednesday, October 10, 2001 10:59 AM

Dear Dr. D'Pankar Banerji,

I would be grateful if you could send me the reference list you mentioned in embryo mail #1439. Thank you.

------------------------------------------------------------------------

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From: "Francis Tekpetey" <Francis.Tekpetey@lhsc.on.ca>

To: <ishani6@sancharnet.in>

Subject: Embryomail posting on ICSI

Date: Thursday, October 18, 2001 5:01 AM

Dear Dr. Banerji:

Your recent Embryomail posting on ICSI is very informative. I would appreciate it if you can send me a list of the 18 references you cited.

Thank you.

Dr. Francis Tekpetey

REI Program

London Health Sciences Centre

London, Ontario, Canada.

Email: francis.tekpetey@lhsc.on.ca

From: "Punjabi, Usha" <Usha.Punjabi@uza.be>

To: "'D'Pankar Banerji'" <ishani6@sancharnet.in>

Subject:

Date: Monday, October 22, 2001 2:19 AM

Dear Dr.D'Pankar Banerji

Your comments on the Embryo Mail concerning ICSI were interesting.

I would be very much obliged to receive the appropriate references

concerning the same.

Thank you in advance.

Usha Punjabi

Chief Embryologist

Centre for Reproductive Medicine

University Hospital Of Antwerp

Wilrijkstraat 10

2650 Edegem

BELGIUM

Dear dr. D'Pankar Banerji,

I red your very interesting paper ( Should we do ICSI at all ? )in
Embryo Mail News - 1439. Please, send me the references -as much as
possible.

Thank you for your courtesy
Best Regards:

Tamas Korosi

H-9026 Gyor
Kaali Inst, IVF Unit
Szabadrev u. 11.
HUNGARY
kota@gyor.kaali.hu

To ,

Editor in Chief

Mr.arun Purie

INDIA TODAY

Living Media India Limited

F-14/15, Connaught Place

New Delhi 110001

Dear Sir ,

I will be highly obliged if you kindly go through the article I am sending to you published in reputed International embryo mail news.( Should we do ICSI at all ? )

It is on intracytoplasmic sperm injection(ICSI) ,injecting single sperm into the human egg ,to overcome male infertility.

I am sending you the article with references and the international response including USFDA, which I received after the publication.

It is for the sake of infertile couple receiving treatments without knowing the complications of the procedure.

I think you will be the best judge whether facts of the procedure should be made available to general population or not.

With best regards

I remain ,Sincerely yours

Dr.D’Pankar Banerji

3.12.2001